The economy of Trujillo Alto has relied mostly on agriculture, particularly sugarcane, coffee, tobacco, and minor fruits. Cattle ranching is also a source of economy in Trujillo Alto. In recent years, commerce and industry have become integral parts of the economy of the city. Trujillo Alto is the site of several factories of nutritional products, wood, metal, electrical machinery, and others. There are also stone quarries in town for the production of building materials
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